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KMID : 0370219860300020068
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Yakhak Hoeji
1986 Volume.30 No. 2 p.68 ~ p.72
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Effect of Sodium Taurodeoxycholate on the Disposition and Elimination of Methylene Blue in the Rats of Experimental Hepatic Failure
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권오승/Kwon OS
심창구/이민화/김신근/Shim CK/Lee MH/Kim SK
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Abstract
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Effect of sodium taurodeoxycholate (TDC) on the pharmacokinctics of methylene blue (MB) was investigated in the rats of experimental hepatic failure induced by CCl4. Intravenous infusion of TDC increased the distribution volume of central compartment (Vd1) and the total body clearance (CLt) of MB. Increased lipophilicity through ion-pair formation with TDC seemed to be the probable cause of increased Vd1, and CLt.
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